Overview
Work History
Education
Skills
Affiliations
Grants won
Professional development and training
Publications
Training
Timeline
Generic

Aloysius Loglo, PhD

Kumasi

Overview

2
2
years of professional experience

Work History

Postdoctoral Research Fellow

KCCR
Kumasi
12.2023 - Current

Postdoctoral Research Fellow in the One Health Bacteriology group where I perform the following roles:

  • Contribute to grant application and manuscript writing.
  • In consultation with the Principal Investigator, develop and document research methods and protocols in compliance with funding agency requirements.
  • Manage and prepare ethics submissions, amendments, informed consent forms, study guides, case report forms, and other related documents.
  • Ensure the maintenance of all relevant study documents and make them available for conducting all studies and inspection by appropriate ethics committees and regulatory bodies.
  • Coordinate project activities at all sites.
  • Coordinates journal and monthly group meetings across three main Ghana, Tanzania, and Germany centers.
  • Responsible for students' supervision and general coordination of students' research work.
  • Present at academic conference and seminars.

Quality Assurance Officer

KCCR
Kumasi
01.2023 - 12.2023
  • Project: IQVIA COVID Trial

Funded by Shionogi, China, a Phase 3, multicenter, randomized, double-blind,24-week study of the clinical and antiviral effect of S-217622 compared with placebo in non-hospitalized participants with COVID-19.

  • Perform assessment of expectation to receive mAbs or Outpatient IV Remdesivir
  • Report and document Adverse Event/Serious Adverse Event
  • Perform investigational product accountability and compliance
  • Make CRF entries, corrections and manage queries
  • Manage institutional review board communications and submissions
  • Maintain investigator site file
  • Send reminder of study diary completion
  • Retrieve and review of study diary, EQ-5D-5L Questionnaire and SF-36V2 Questionnaire, participant study medication log.

Doctoral Researcher

University of Surrey, Guildford, UK/KCCR, Ghana
Guildford

Funded by the Wellcome Trust, this project investigated the role of coagulation and diet in the pathogenesis of Buruli ulcer.

These roles were partly performed in the UK and at KCCR in Ghana.

My leading role was as a project manager and in charge of four study sites when in the UK or Ghana.

  • Microbiology: Growth enhancement of M. Marinum, M.Liflandi, MMDL, M. Ulcerans 1615 using several substances
  • Molecular biology: Cloning Sec61 into PNFL1_C.
  • Molecular biology: Stable transfection using Hec293 Trex cells with hygromycin and Epimer as selective markers.
  • Clinical research: recruiting calibration group in the UK and coordinating study from Ghana.
  • Prepared protocols for blood collection, sample processing, storage, and growth enhancement assay.
  • Prepared risk assessment and management plan for assays.
  • Applied for ethics approval for the aspect related to obtaining blood from participants in Ghana and the United Kingdom.
  • Prepared a monthly progress report to the Principal Investigator.
  • Working in collaboration with the Skin NTD group, KCCR to source study participants and samples to investigate the role of coagulation and diet in the pathogenesis of Buruli ulcer.
  • Led recruitment of study participants - obtaining consent, taking blood samples, swab, or fine needle aspirate for laboratory diagnosis by good clinical and good laboratory practice.
  • Led administration of food frequency questionnaire (FFQ), and 24-hour recall of Buruli ulcer cases and controls
  • Prepared monthly progress reports for UK and Ghana collaborators throughout the study period. Processed samples and safely stored them under good laboratory practice to be used for the measurement of levels of micronutrients and inflammation markers in the serum of 160 study participants using ELISA and bead-based flow cytometry techniques.
  • Created and led a team of postgraduate medical researchers to conduct a systematic review and meta-analysis to determine the role of nutrition in the pathogenesis of NTDs.
  • Data obtained from FFQ and 24-hour recall, measurement of the micronutrients and inflammation markers, and the systematic review and meta-analysis were analyzed using GraphPad Prism, SPSS, and R software.
  • Applied and won three prestigious grants during my PhD training to expand my research and for capacity building for personnel at Buruli ulcer endemic sites in Ghana.
  • Prepared intermediary and full progress reports to the study funders.

Laboratory Lead

KCCR
Kumasi
  • Project: Buruli-RifDACC TRIAL

Funded by NHIR, UK, this randomized controlled trial evaluating the effect of high dose Rifampicin and Dialkylcarbamoyl chloride (DACC)-coated dressings on outcomes in Mycobacterium ulcerans disease

  • Led a team of laboratory scientists to undertake handling, diagnosis and other laboratory procedures are performed according to approved Standard Operating Principles and protocols.

Graduate Research Associate (Part-time)

KCCR
Kumasi
  • Project: Buruli-NOX

Funded by EDCTP, this randomized controlled trial evaluating a nitric oxide generating dressing (EDX110) to improve the management of Buruli ulcer disease

  • Delegated to play roles during clinic visits such as consenting, updating study CRF, and using the Aranz Silhouette digital camera for wound management according to study protocol.

Graduate Research Associate

KCCR
Kumasi
  • Project: BURULIPATH

Contributed to the Burulipath project as a member of the Skin-NTD Research group under MRC/DFID.

  • Performed routine and specific Molecular Biology and immunological assays as required by the Principal Investigator.
  • Conducted field activities and managed projects by performing routine checks and health assessments while ensuring compliance with safety protocols.
  • Performed various administrative tasks to ensure smooth day-to-day operations.
  • Draft manuscripts for paper publications with PI.

MPhil Postgraduate Researcher

KCCR
Kumasi
  • Project: BURULIPATH & WHO DRUG TRIAL

The BURULIPATH project was funded by MRC/DFID to investigate the vaccine potential of polyketide synthase domains previously tested in mice for Buruli ulcer disease.

  • WHO DRUG TRIAL funding was a WHO-led drug trial on oral treatment for patients with Buruli ulcer
  • Assisted in the coordination of both studies and play other roles in the laboratory as follows: Conducting ELISA assays, Flow Cytometry (assisted), Whole blood stimulation assays, DNA and RNA extraction, PCR (Polymerase chain reaction), Gel Electrophoresis, Interpretation of Results, Ficcol gradient centrifugation technique, Microscopy, fluorescent thin layer chromatography for detection of mycolactone in Swab and FNA samples
  • Obtaining tissue samples (Swabs, Fine Needle Aspirate (FNA), Blood samples (EDTA, Heparin tubes).

Research Assistant

KCCR
Kumasi
  • Project: HEPIK.

Funded by the Royal Society, investigated the Hepatitis B and HIV co-infection in Kumasi (HEPIK), Ghana

  • Performed assays on blood samples for HBV (Hepatitis B virus) using (i) Qualitative immunochromatographic test (Rapid test) and ii) ELISA technique
  • Qualitative and differential detection of HIV-1 and HIV-2 using an indirect solid-phase enzyme immunoassay (EIA)
  • Data entry and organization of laboratory results.
  • CD4 Count test.

Intern

Komfo Anokye Teaching Hospital
Kumasi
  • Preparing microbiology media to be used in culturing patient samples
  • Processing of samples (blood, cerebrospinal fluid, wound swab, urine etc.)
  • Performing sample culturing, identification and sensitivity, Gram staining, Ziehl-Neelsen (ZN) technique for acid-fast bacilli and microscopy.

Education

PhD Biosciences and Medicine - Immunology

University of Surrey
Guildford, UK
01.2023

MPhil Immunology -

Kwame Nkrumah University of Science and Technology (KNUST)
Kumasi, Ghana
01.2016

Professional Diploma in Project Design and Management -

Liverpool School of Tropical Medicine
UK
01.2015

B. Ed Science - Biology Major -

University of Education Winneba
Winneba, Ghana
01.2009

Skills

  • Project management
  • Project design
  • Data collection and analysis
  • Data management and entry
  • Fieldwork
  • Informed consent process
  • Ethics approval process
  • Compliance with FDA regulations
  • Grant writing
  • Scientific/medical writing
  • Clinical trials
  • Nutrition research
  • Immunology research

Affiliations

  • Royal Society of Biology
  • Microbiology Society
  • Ghana Science Association

Grants won

  • Proposal to Train Health Workers and to Implement Case Detection for Skin-NTD in Ghana, Co-PI, Coordinator, World Health Organization, Geneva, Switzerland, $50,000.00, June 2021, December 2021
  • Impact of nutritional biomarkers in the pathogenesis of Buruli ulcer disease, PI, Nestle Foundation, Lausanne, Switzerland, $14,773.00, November 2021, November 2022
  • The role of Vitamin C in the pathogenesis of Buruli ulcer, PI, College of Health Sciences, Kwame Nkrumah University of Science Technology, Kumasi, Ghana, $1,631.73 (GHC10,000.00), December 2021, November 2022

Professional development and training

  • Food and Drugs Authority, Ghana, Good Clinical Practice Workshop, Ghana, August 29-30, 2023
  • Training of Health Workers and community-based surveillance Volunteers on the identification of Neglected Tropical Diseases of the skin (Outreach grant) in 5 endemic districts, Ghana, August 2021
  • Setting Operational Research Agenda for skin-NTDs (Outreach grant), KNUST, July 2021
  • Global Health and Infectious Diseases Research Group on 3-day Workshop Good clinical practice, KCCR, Ghana, October 2020
  • Immunology: from Chemistry to Metabolism, Leiden University Medical Centre, The Netherlands, October 2020
  • New Buruli ulcer reporting forms, World Health Organization (WHO), Geneva, Switzerland, August 2020
  • Introduction to teaching and learning, DHE, Assessment and Feedback, University of Surrey, Guildford, United Kingdom, February 2019
  • Demonstration in the laboratory, DHE, University of Surrey, Guildford, United Kingdom, January 2019
  • Cryogen gas safety, University of Surrey, Guildford, United Kingdom, July 2018
  • Tissue culture induction training, University of Surrey, Guildford, United Kingdom, July 2018
  • Ethics/SAFE workshop, University of Surrey, Guildford, United Kingdom, April 2018
  • Phlebotomy training at the University of Surrey, Clinical Investigation Unit (CIU) in the AX building (23AX00), Guildford, United Kingdom, April 2018
  • Health, safety and risk assessment workshop, University of Surrey, Guildford, United Kingdom, March 2018
  • STA Compact Max training, Diagnostica Stago, Bath, UK, February 2018
  • Workshop on good clinical practice/good laboratory practices, Buruli ulcer Research group at KCCR, KNUST, Ghana, July 2017
  • Workshop on Fluorescent Thin Layer Chromatography as a diagnostic test for Buruli ulcer disease, Buruli ulcer Research group at KCCR, KNUST, Ghana, July 2017
  • Knowledge Management and Research Translation Workshop, USAID at KCCR, Kumasi, Ghana, February 2017

Publications

  • Micronutrient-deficient diets and possible environmental enteric dysfunction in Buruli ulcer endemic communities in Ghana: lower dietary diversity and reduced serum zinc and vitamin C implicate micronutrient status a possible susceptibility factor, Loglo AD, Antwi PB, Abass KM, Osei-Mireku S, Amofa G, Ofori E, Adjei J, Oppong MN, Phillips RO, Annan R, Engel B, medRxiv, 2024
  • Implementation of an integrated control programme for neglected tropical diseases of the skin in Ghana: The essential role of the laboratory, Agbanyo A, Agbavor B, Gyabaah S, Ntiamoah MO, Dornu O, Antwi PB, Loglo AD, Abass MK, Amofa G, Kotey NK, Quao B, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2024
  • The role of nutrition in the pathogenesis of neglected tropical diseases: systematic review and meta-analysis, Loglo, Aloysius, Wilfred Aniagyei, Monika Mira Vivekanandan, Abigail Agbanyo, Evans Adu Asamoah, Richard Odame Phillips, Reginald Annan, Barbara Engel, and Rachel E. Simmonds, Access Microbiology, 2024
  • Clinical and microbiological predictors of healing in Buruli ulcer disease, Agbavor B, Agbanyo A, Loglo AD, Antwi PB, Ackam N, Adjei J, Frimpong V, Boampong K, Frimpong M, Addo MG et al, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2024
  • Role and capacity needs of community-based surveillance volunteers in the integrated management of skin neglected tropical diseases (skin NTDs): a qualitative study from central Ghana, Owusu L, Tuwor RD, Ackam N, Loglo A, Agbavor B, Agbanyo A, Dornu O, Antwi PB, Oppong MN, Adjei JK, Frimpong V, Abass MK, Novignon J, Asiedu K, Laryea DO, Amoako YA, Phillips RO, BMC Public Health, 2023, https://doi.org/10.1186/s12889-023-16015-w
  • Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions, Hsieh, L.T.H., Dos Santos, S.J., Hall, B.S., Ogbechi, J., Loglo, A.D., Salguero, F.J., Ruf, M.T., Pluschke, G. and Simmonds, R.E., PLoS Pathogens, 2022
  • Co-infection of HIV in patients with Buruli ulcer disease in Central Ghana, Amoako, Y. A., A. D. Loglo, M. Frimpong, B. Agbavor, M. K. Abass, G. Amofa, E. Ofori, E. Ampadu, K. Asiedu, Y. Stienstra, M. Wansbrough-Jones, T. van der Werf and R. O. Phillips, BMC Infectious Diseases, 2021
  • Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial, Phillips,R.O., Jérôme Robert, Kabiru Mohamed Abass, William Thompson…Aloysius Dzibordzi Loglo, et al., Lancet (London, England), 2020
  • Paradoxical reactions in Buruli ulcer after initiation of antibiotic therapy: Relationship to bacterial load, Frimpong M, Agbavor B, Duah MS, Loglo A, Sarpong FN, Boakye-Appiah J, et al., PLoS Neglected Tropical Diseases, 2019
  • IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection, Loglo, A. D., M. Frimpong, M. Sarpong Duah, F. Sarfo, F. N. Sarpong, B. Agbavor, J. K. Boakye-Appiah, K. M. Abass, M. Dongyele, M. Frempong, S. Pidot, M. Wansbrough-Jones, T. P. Stinear, V. Roupie, K. Huygen and R. O. Phillips, PeerJ, 2018
  • Recruiting for the WHO drug trial, including obtaining informed consent of patients and screening. - Coordinating the World Health Organization Buruli ulcer drug trial for 4 clinical trial sites. The coordination roles included provision of logistics for the sites, ensuring data synchronization, monitoring and evaluation on a monthly bases, assisting PI preparing reports to WHO, planning of stakeholder meetings, development of newsletter for the local trial groups. - Photography: wound measurement with Aranz Silhouette digital camera., Sarfo, F. S., Owusu, D., Ackam, N., Loglo, A., Agbavor, B., Agbanyo, A., Dornu, O., Antwi, P. B., Oppong, M. N., Adjei, J. K., Frimpong, V., Abass, M. K., Novignon, J., Asiedu, K., Laryea, D. O., Amoako, Y. A., Phillips, R. O., 2017
  • Microscopy for Acid Fast Bacilli: A Useful but Neglected Tool in Routine Laboratory Diagnosis of Buruli Ulcer, Frimpong M, Sarpong-Duah M, Beissner M, Saar M, Laing K, Sarpong F, Loglo A, Abass K, Frempong M, Sarfo F, Bretzel G, Wansbrough-Jones M, T. van der Werf, Phillips RO

Training

  • Faculty of Health and Medical Sciences Research Celebration Event, Guildford, United Kingdom, June 2022, Oral Presenter, Buruli ulcer and Nutrition: The role of diet in the pathogenesis of Neglected Tropical Diseases
  • University of Surrey, Faculty of Health and Medical Sciences Research Celebration Event, Guildford, United Kingdom, July 2021, Participant, Addressing the escalating global vitamin B12 insufficiency
  • WHO, Geneva, Switzerland, October 2020, Participant, How do we tackle neglected tropical diseases of the skin (Skin NTDS) to reach the 2030 NTD Road Map targets?
  • WHO, Geneva, Switzerland, September 2020, Participant, How can WASH help reach 2030 targets?
  • University of Surrey Doctoral College conference, Guildford, United Kingdom, July 2019, Poster presenter, The role of diet in the pathogenesis of Buruli ulcer
  • Africans in STEM symposium, Cambridge, United Kingdom, June 2019, Poster presentation and 5-minute flash presentation, The role of diet in the pathogenesis of Buruli ulcer
  • WHO meeting on Buruli ulcer and other skin NTDs, Geneva, Switzerland, March 2019, Participant
  • Acid Fast Club Winter meeting, London, United Kingdom, January 2019, Participant
  • Acid Fast Club 62nd Summer meeting, Oxford, United Kingdom, July 2018, Participant
  • Best Practices in Grant Financial Management, KNUST, Ghana, June 2017, Participant
  • Meeting on Buruli ulcer Control and Research, WHO Headquarters, Geneva, Switzerland, March 2017, Participant

Timeline

Postdoctoral Research Fellow

KCCR
12.2023 - Current

Quality Assurance Officer

KCCR
01.2023 - 12.2023

Doctoral Researcher

University of Surrey, Guildford, UK/KCCR, Ghana

Laboratory Lead

KCCR

Graduate Research Associate (Part-time)

KCCR

Graduate Research Associate

KCCR

MPhil Postgraduate Researcher

KCCR

Research Assistant

KCCR

Intern

Komfo Anokye Teaching Hospital

PhD Biosciences and Medicine - Immunology

University of Surrey

MPhil Immunology -

Kwame Nkrumah University of Science and Technology (KNUST)

Professional Diploma in Project Design and Management -

Liverpool School of Tropical Medicine

B. Ed Science - Biology Major -

University of Education Winneba
Aloysius Loglo, PhD